Rapid discovery and manufacture of next-generation cell therapies

Cell therapies are a new category of living medicines with curative potential. Cells are collected from a patient, genetically modified to create highly personalized therapies, and then reinfused into the patient. A small number of these therapies have moved from clinical trials to market approval, but the industry must address challenges in manufacturability, scalability and cost if the full potential for patients is to be realized …

MassVentures START Funds Give Kytopen an Early Boost

MassVentures awarded Kytopen a “Stage I” $100,000 grant through our Small Business Innovation Research (SBIR) Targeted Technologies (START) program in 2019. The funding allowed the Kytopen team to sell their product by attending conferences, trade shows, and working with partners to scale up production. While such activities are critical for startups seeking to raise capital and grow, SBIR grants don’t cover those expenses.

MilliporeSigma Awards Grants to Biotechs Tackling Cancer and Cardiovascular Disease

In addition to the Advance Biotech Grant, Merck recently named Kytopen as the winner of its biotech start-up program in the U.S. Massachusetts-based Kytopen won a sponsored residency at LabCentral, a first-of-its-kind shared laboratory space. As a resident, the biotech works to further develop its proprietary Flowfect™ technology for non-viral delivery of molecules into hard-to-transfect …

Breaking the Bottleneck in Genetic Engineering

Building on expertise devising microfluidics tools for use in small-scale biological systems, Buie’s lab invented a tiny pipette equipped with electrodes through which cells flow. As cells move through the pipette’s tiny channel, they are exposed to an electric field with just the right amount of current to open their pores. “So now we can continuously flow cells and deliver DNA into them for reprogramming at a rate that is 10,000 times …

The Engine announces investments in first group of startups

In January, MIT announced the creation of The Engine Working Groups, charged with guiding the development of Institute policies and procedures related to The Engine, and an Idea Bank for MIT community members and alumni to provide input. In February, the program secured funding and established its leadership, and in April it closed its first investment fund with more than $150 million to support the startups …